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This content is not meant to replace a conversation with a healthcare provider. A healthcare provider can evaluate your symptoms and make appropriate clinical decisions.

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HAE is a rare, unpredictable disease that can be life‑threatening

During an attack, people with HAE may experience many complications

face

  • Problems speaking clearly
  • Poor vision from swollen face causing eyes to close
  • Swells may cause fear and shame

Throat/AIRWAY

  • Shortness of breath
  • Difficulty speaking
  • Choking and fear of death from being unable to breathe
  • Highest emotional impact compared to other attack locations
  • Hospitalization more likely to occur

Hands & Arms

  • Lack of ability to hold objects (phone, pen, glass/cup)
  • Difficulty texting or typing
  • May make it difficult to give oneself an injectable or IV HAE medication
  • Embarrassment being seen in public

Stomach

  • Mild to severe stomach pain with nausea, vomiting, and/or diarrhea
  • Abdominal pain can restrict ability to move

Genitals

  • More-frequent attacks during periods, giving birth through C-section, and breastfeeding
  • Estrogen-containing birth control pills can trigger HAE attacks
  • Potential attacks during childbirth

Legs & Feet

  • Difficulty walking or running
  • Cannot fit into shoes

With never knowing when, where, why, and how HAE will present itself, there comes naturally a lot of anxiety.

— Jamie, real person living with HAE

Swelling in HAE is a result of EXCESS BRADYKININ PRODUCTION

Bradykinin is a natural substance found in the body that plays a role in inflammation and swelling

Slide to see what blocking the effects of bradykinin can do to help people with HAE.

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Overproduction
of bradykinin

Blocking the
excess bradykinin

Most people with HAE have a genetic disorder that causes them to produce too much bradykinin, resulting in swelling throughout the body

Blocking excess bradykinin can help prevent, shorten, or stop HAE swells

HAE attacks may last for days if not treated

Tap the chart to learn more

Swelling develops gradually
over approximately

Swelling develops gradually
over approximately

Swelling resolves over
approximately

24 HOURS

PLATEAUS

48-120 HOURS

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GET THE FACTS

HAE generally runs in families. If you have a relative with HAE, you are more likely to have it, too. Both men and women have HAE equally

Estrogen levels can affect both the frequency and severity of attacks. Since women have more estrogen in their bodies, HAE can be worse for them

HAE attacks that only affected the face were linked to more missed work days (26.5%) and worse productivity (48.2%) than attacks affecting other parts of the body

In a 2017 survey of 445 people with HAE in the United States, 35.3% reported feeling anxiety and 20.9% reported feeling depression

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Burden of HAE Management

Understand the trade-offs
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Living with HAE

See how HAE burdens lives

References

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Real person living with HAE.

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