This content is not meant to replace a conversation with a healthcare provider. A healthcare provider can evaluate your symptoms and make appropriate clinical decisions.

Another swell.

Another swell.

Another swell.

Another swell.

Another day alone.

Another day of stares and whispers.

Another day of canceled plans.

Another day and night of terrors.

Real person living with HAE.

Is current HAE management forcing people to make trade-offs?

While current HAE management may help, you may be making trade-offs among:

EFFECTIVENESS

How well it works

side effects

How well it is tolerated

Convenience

How easy it is to take or carry around

Don’t miss what’s next in HAE

Four real people with HAE. Four unique stories.

deflate HAE

TOGETHER

How do you or a loved one live with the burdens and trade-offs of HAE and its management?

What is your Deflate HAE Identity?

CLICK Start Assessment HERE

Answer 5 quick questions and discover whether you are:

Answer 5 quick questions and discover whether you are:
Every person’s HAE journey is different and has different needs. By answering 5 quick questions about your unique experiences, you can discover your own HAE Identity AND help shape programs and resources to take the air out of HAE.

Quiz Visual
Profile Result Profile Result

Complete Your Profile

Become a part of the deflate HAE community

Share your information and join the more than 1,200 people who have already
signed up. Get the latest updates on deflate HAE, including community
stories, engaging interactive tools, and valuable resources.

All fields and checkboxes are required.

swelling hand

Important Role of Bradykinin

Woman holding balloons representing Tolerability, Convenience, & Efficacy

Burden of HAE Management

References

  1. Abdulkarim A, et al. Hereditary angioedema. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2023. https://www.ncbi.nlm.nih.gov/books/NBK482266/
  2. Anderson J, et al. Allergy Asthma Clin Immunol. 2021;17(1):60.
  3. Angioedema Centers of Reference and Excellence. Who we are. Accessed May 23, 2024. https://acare-network.com
  4. Aygören-Pürsün E, et al. Allergy. 2013;68(8):1034-1039.
  5. Aygören-Pürsün E, et al. Orphanet J Rare Dis. 2014;9(99):1-9.
  6. Azmy V, et al. Allergy Asthma Proc. 2020;41(Suppl 1):S18-S21.
  7. Banerji A, et al. Allergy Asthma Proc. 2015;36:213-217.
  8. Banerji A, et al. Ann Allergy Asthma Immunol. 2020;124:600-607.
  9. Betschel SD, et al. J Allergy Clin Immunol Pract. 2023;11(8):2315-2325.
  10. Betschel SD, et al. Allergy Asthma Clin Immunol. 2024;20(43):1-8.
  11. Betschel SD, et al. Allergy Asthma Clin Immunol. 2025;21(25):1-11.
  12. Broderick L, et al. Orphanet J Rare Dis. 2025;20(16):1-11.
  13. Busse PJ, et al. N Engl J Med. 2020;382:1136-1148.
  14. Busse PJ, et al. J Allergy Clin Immunol Pract. 2021;9(1):132-150.
  15. Castaldo AJ, et al. Ann Allergy Asthma Immunol. 2025 May 23:S1081-1206(25)00258-3.
  16. Chong-Neto HJ. World Allergy Organ J. 2023;16(3):100758.
  17. Covella B, et al. Future Pharmacol. 2024;4(1):41-53.
  18. Data on file, Pharvaris.
  19. Everyday Health. Speaking hereditary angioedema (HAE): a glossary of terms used to describe symptoms, tests, treatments, and more. Accessed May 23, 2025. https://www.everydayhealth.com/hereditary-angioedema/glossary-of-terms-used-to-describe-symptoms-tests-treatments-and-more/
  20. Farkas H, et al. Clin Transl Allergy. 2021;11(4):e12035.
  21. Ferreira G, et al. J Investig Allergol Clin Immunol. 2023;33(5):332-362.
  22. Firazyr [prescribing information]. Shire Human Genetic Therapies, Inc. Accessed June 6, 2025. https://www.accessdata.fda.gov/drugsatfda_docs/label/2024/022150s016lbl.pdf
  23. Food and Drug Administration. The voice of the patient - hereditary angioedema. Published May 2018. Accessed May 23, 2025. https://www.fda.gov/files/about%20fda/published/The-Voice-of-the-Patient---Hereditary-Angioedema.pdf
  24. Geba D, et al. J Drug Assess. 2021;10(1):51-56.
  25. Gülbahar O. Balkan Med J. 2021;38(2):73-81.
  26. Haegarda [prescribing information]. CSL Behring GmbH. Accessed June 6, 2025. https://www.fda.gov/media/105611/download
  27. Hereditary Angioedema Canada. Learning to live with hereditary angioedema. Accessed May 23, 2025. https://haecanada.org/wp-content/uploads/sites/64/2020/10/HAE-Canada-patient-booklet-Updated-2020-v2.pdf
  28. Hereditary Angioedema International. About HAEi. Accessed May 23, 2025. https://haei.org/about-haei/
  29. Hereditary Angioedema International. Frequently asked questions. Accessed May 23, 2025. https://haei.org/hae/faq/
  30. Hsu FL, et al. Allergy Asthma Clin Immunol. 2022;18(64):1-9.
  31. Jean-Baptiste M, et al. Orphanet J Rare Dis. 2022;17(232):1-12.
  32. Johnston DT, et al. Allergy Asthma Proc. 2020;41:S43-S46.
  33. Leibovich-Nassi I, et al. Clin Rev Allergy Immunol. 2021;61:15-28.
  34. Lima H, et al. Front Allergy. 2023;10(4):1-5.
  35. Lo SH, et al. Pharmacoecon Open. 2022;6(2):231-239.
  36. Longhurst HJ, et al. Br J Hosp Med (Lond). 2019;80(7):391-398.
  37. Lumry WR, et al. Allergy Asthma Proc. 2020;41(Suppl 1):S08-S13.
  38. Manning ME. Allergy Asthma Proc. 2020;41(Suppl 1):S22-S25.
  39. Maurer M, et al. Allergy. 2022;77(7):1961-1990.
  40. Mayo Clinic. Hives and angioedema. Accessed May 23, 2025. https://www.mayoclinic.org/diseases-conditions/hives-and-angioedema/symptoms-causes/syc-20354908
  41. National Organization for Rare Disorders. Hereditary angioedema. Accessed May 23, 2025. https://rarediseases.org/rare-diseases/hereditary-angioedema/
  42. Pagnier A, et al. Pediatr Allergy Immunol. 2024;35:e14268.
  43. Purdue University. College of Science. Career development. Accessed May 23, 2025. https://www.purdue.edu/science/careers/what_can_i_do_with_a_major/Career%20Pages/immunologist.html#:~:text=Immunologists%20are%20research%20scientist
  44. Radojicic C, et al. Allergy Asthma Proc. 2021;42(3):S4-S10.
  45. Riedl MA, et al. Ann Allergy Asthma Immunol. 2017;119(1):59-64.
  46. Riedl MA, et al. Allergy. 2020;75(11):2879-2887.
  47. Riedl MA, et al. Allergy Asthma Proc. 2021;42:S17-S25.
  48. Savarese L, et al. Allergy Asthma Proc. 2021;42(1):e1-e7.
  49. Shamanaev A, et al. Front Physiol. 2023;14:1146834:1-13.
  50. Smith TD, et al. Ann Allergy Asthma Immunol. 2024;133:380-390.
  51. Soteres DF, et al. Clin Case Rep. 2021;9(11):e05086.
  52. Takhzyro [prescribing information]. Dyax Corp. Accessed June 6, 2025. https://www.accessdata.fda.gov/drugsatfda_docs/label/2023/761090s010lbl.pdf
  53. US Hereditary Angioedema Association. Conquering hereditary angioedema together. Accessed May 23, 2025. https://www.haea.org/
  54. US Hereditary Angioedema Association. About hereditary angioedema. Accessed May 23, 2025. https://www.haea.org/pages/p/what_is_hae#:~:text=Symptoms%3A%20HAE%20Attacks,those%20in%20the%20same%20family%204
  55. US Hereditary Angioedema Association. Treatments. Accessed May 23, 2025. https://www.haea.org/pages/p/treatments
  56. Wedner HJ, et al. J Allergy Clin Immunol Pract. 2021;9(6):2305-2314.e4.
  57. Zacek L. Nursing. 2022;52(12):44-50.
  58. Zanichelli A, et al. Ann Allergy Asthma Immunol. 2016;117:394-398.
  59. Zuraw BL. World Allergy Organ J. 2010;11:S25-S28.
  60. Zuraw BL, et al. Allergy Asthma Proc. 2025;46:209-217.